克罗米酚对男性高于促性腺素性功能减退症有效

纽约（路透社健康台湾版）1同年四日报道：据发表在12同年出台湾版的《生育与不育》杂志的一项统计数据声称克罗米胺对部分低促普遍性腺素普遍性功能减退的男普遍性病征不利。来自伯明翰阿拉巴马该大学的该统计数据的第一作者Scott J. Whitten博士在接受路透通讯社采访时真是：“原发普遍性或获得普遍性HH病征在接受侵害普遍性更大和更为昂贵的病人（例如针头促普遍性腺激素类）前透过4个同年的克罗米胺试验普遍性病人是不利的。”Whitten博士和熟人研究了克罗米胺对10名HH男普遍性病征（HH是导致男普遍性不育的少见因素）是否有效。统计数据指克罗米胺病人1年后，4名在此之后(氏)综合征病征中都只有一名病征的受精卵电导率增加而全下丘脑功能减退症病征的受精卵缺失症状原则上没给与改善。相反，该统计数据声称3名成年发病的原发普遍性HH男普遍性病征经过3个同年克罗米胺的病人受精卵电导率有了明显增加。目前为止该组病征已有两名恢复了子代。Whitten博士真是：“除非对克罗米胺病人没反应，我们就会因为抑制剂停止对病征用作该药物。”之前作者回顾真是：“因为条件有限，对HH病征促普遍性腺激素抑制剂和克罗米胺的随机研究不足以透过，然而利用多系列的严格选择标准对病征透过基准也许帮助更进一步验证克罗米胺恢复男普遍性低子代的有效普遍性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

撰稿：蓝色妄想

撰稿： 张靖